Polypeptides and peptides, nucleic acids coding for them, and their use in the field of tumor therapy, inflammation or immunology

US5981277A · kind A · utility

Assignee

• N.V. Innogenetics S.A. · BE

Inventors

• Lucia Fransen · Zevergem, BE
• Kathleen Devos · Laarne, BE
• Andre Van De Voorde · Lokeren, BE
• Hugo Van Heuverswyn · Laarne, BE

Key dates

• Filing date: Oct 13, 1994
• Grant date: Nov 9, 1999
• Expiry date: Oct 13, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/91
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An isolated and purified nucleic acid comprising: PA1 a nucleotide sequence which has at least 50% sequence identity, with any of the nucleotide sequences coding for polypeptides containing in their pepridic chains: PA2 the amino acid sequence of 311 amino acids of FIGS. 2 or 3, PA2 or a fragment of this sequence being such that it is able to produce antibodies capable of forming a complex with the amino acid sequence of FIG. 2 or 3, PA2 or an amino acid sequence having a percentage of homology of at least 50%, with the amino acid sequence of FIG. 2 or 3, PA2 or a sequence able to form a complex with antibodies raised against the amino acid sequence of FIG. 2 or 3, PA2 or against pep1(m) or pep1(h) PA2 or against pep2(m) or pep2(h) PA2 or against pep3(m) or pep3(h) PA1 a nucleotide sequence which hybridizes with nucleotide sequence coding for said polypeptides, PA2 or the above-indicated nucleotide sequences wherein T is replaced by U, PA2 or the complementary sequences of the above-mentioned nucleotide sequences and vectors containing necessary elements to promote the expression in a cellular host of polypeptides coated by nucleic acids thereof.