Compositions and methods to regulate calmodulin gene expression, and uses thereof for influencing cell growth and differentiation
US5981279A · kind A · utility
16Cited by
0References
19Claims
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Inventor
Key dates
| Filing date | Nov 8, 1996 |
| Grant date | Nov 9, 1999 |
| Priority date | — |
| Expiry date | Nov 8, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Constructs encoding calmodulin antisense molecules are disclosed. These constructs may be used to advantage to inhibit proliferation of malignant cells. The invention further comprises monoclonal antibody studded liposomes to facilitate cell-type specific delivery of the antisense calmodulin constructs. To enhance cell-type specific expression of calmodulin antisense sequences, cell-type specific promoters are employed to drive expression of the antisense molecules in targeted tissues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.