Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith

US5981513A · kind A · utility

Assignee

• Adolor Corporation · US

Inventors

• Lawrence I. Kruse · Haddonfield, US
• An-Chih Chang · Phoenixville, US
• Diane L. DeHaven-Hudkins · Chester Springs, US
• John J. Farrar · Chester Springs, US
• Forrest Gaul · Douglassville, US
• Virendra Kumar · Paoli, US
• Michael Anthony Marella · Philadelphia, US
• Alan L. Maycock · Malvern, US
• Wei Zhang · San Diego, US

Key dates

• Filing date: Mar 21, 1998
• Grant date: Nov 9, 1999
• Expiry date: Mar 21, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula II having the structure: ##STR1## wherein X.sub.4, X.sub.5 ; PA1 R.sub.1, R.sub.2 ; and PA1 Ar and n are as described in the specification.