Human ubiquitin conjugating enzyme
US5981699A · kind A · utility
4Cited by
0References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 23, 1994 |
| Grant date | Nov 9, 1999 |
| Priority date | — |
| Expiry date | May 23, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2217/05
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention concerns a novel human ubiquitin-conjugating enzyme which is implicated in the ubiquitin-mediated inactivation of cell-cycle regulatory proteins, partucularly p53. The present invention makes available diagnostic and therapeutic assays and reagents for detecting and treating transformed cells, such as may be useful in the detection of cancer. The present invention also provides reagents for altering the normal regulation cell proliferation in untransformed cells, such as by upregulating certain cell-cycle checkpoints, e.g. to protect normal cells against DNA damaging reagents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.