Process for indinavir intermediate

US5981759A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Yongku Sun · Bound Brook, US
• Frank P. Gortsema · Pleasantville, US
• Carl Leblond · Gilbertsville, US
• Kai Rossen · Hanau, DE

Key dates

• Filing date: Jun 17, 1998
• Grant date: Nov 9, 1999
• Expiry date: Jun 17, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D263/52
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An intermediate in the synthesis of indinavir is prepared by iodohydroxylating an allyl acetonide by hypoiodous acid generated in situ from sodium hypochlorite and sodium iodide. ##STR1##