Contrast agents for MRI using a manganese compound and kojic acid

US5985245A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Klaes Golman · Hørsholm, DK
• Goran Pettersson · Hjärup, SE
• Arne Berg · Sandvika, NO
• Jo Klaveness · Oslo, NO
• Pal Rongved · Oslo, NO
• Peter Leander · Lund, SE
• Ib Leunbach · Copenhagen, DK

Key dates

• Filing date: Nov 3, 1997
• Grant date: Nov 16, 1999
• Expiry date: Nov 3, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided a contrast medium composition comprising: (a) a first contrast agent comprising a physiologically tolerable manganese compound, a physiologically tolerable reducing compound containing an .alpha.-hydroxy ketone group, or salt thereof, having a manganese concentration of at least 0.3 mM or being in a dosage unit form containing at least 300 .mu.mol manganese, together with (b) a second contrast agent. Such compositions have been found to be particularly suited to imaging of the liver.