Anti-.alpha.V-integrin monoclonal antibody
US5985278A · kind A · utility
41Cited by
0References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 19, 1995 |
| Grant date | Nov 16, 1999 |
| Priority date | — |
| Expiry date | Dec 19, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a novel monoclonal antibody, a hybridoma cell line producing said antibody, DNA sequences coding for said antibody, and amino acid sequences. The monoclonal antibody, a preferred embodiment of which is named 17E6, has the following properties: PA1 reacting only with the .alpha.V-chain of human .alpha.V-integrins, PA1 blocking the attachment to the integrin substrate of the .alpha.V-integrin bearing cell, PA1 triggering reversal of established cell matrix interaction caused by .alpha.V-integrins, PA1 blocking tumor development, and PA1 showing no cytotoxic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.