Cleaning and disinfecting contact lenses with a protease and chloramine-T or chloramine-B
US5985629A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 12, 1997 |
| Grant date | Nov 16, 1999 |
| Priority date | — |
| Expiry date | Feb 12, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L12/082
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Contact lens are cleaned and disinfected by contacting with an enzyme that functions as a cleaning agent by degrading deposits on the lens, and with an enzyme inhibitor that inhibits remaining enzyme activity and a mild disinfecting agent. If rinsing of the lens is not carried out after cleaning and disinfecting, this procedure prevents eye damage by inhibiting remaining enzyme activity and using a mild disinfectant. Preferred enzymes are proteases such as an acidic aspartic protease, a cysteine protease, a serine protease or a metalloprotease, and preferred enzyme inhibitors function both as an inhibitor and as a mild disinfectant such as chloramine-T, chloramine-B, bacitracin or aryl boronic acids. In a preferred method, the enzyme is subtilisin A and the enzyme inhibitor and disinfectant is chloramine-T. The method may be carried out with a solution containing the enzyme and a tablet containing the enzyme inhibitor and disinfectant or with two tablets where one contains the enzyme and the other contains the enzyme inhibitor and disinfectant or with a multi-layer tablet where an outer layer contains the enzyme and an inner layer contains the enzyme inhibitor and disinfectant. The…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.