Phosphate compounds and their use as medicaments
US5985849A · kind A · utility
8Cited by
2References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 4, 1998 |
| Grant date | Nov 16, 1999 |
| Priority date | — |
| Expiry date | May 4, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound of the formula (I) or salts thereof: ##STR1## wherein X, R.sup.1, Q.sup.1 and Q.sup.2 are as defined in the specification. The compounds have been found to be P2 7-TM G-protein receptor antagonists, especially to the P2 Y2 receptor, and are useful in therapy, for example as anti-inflammatory agents useful in the treatment of a number of inflammatory diseases such as asthma, inflammatory bowel disease, ARDS, psoriasis, rheumatoid arthritis, myocardial ischaemia, COPD, cystic fibrosis, arthrosclerosis, restenosis, peridontal disease, septic shock, osteoarthritis and stroke.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.