Benzoxazine compounds for enhancing synaptic response
US5985871A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 24, 1997 |
| Grant date | Nov 16, 1999 |
| Priority date | — |
| Expiry date | Dec 24, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds having a certain benzoxazine ring system and their precursors are disclosed which are useful for enhancing synaptic responses mediated by AMPA receptors. Also disclosed are methods for preparing such compounds, and methods for their use in treating subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number of excitatory synapses or in the number of AMPA receptors. The invention compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors and for improving memory encoding.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.