Physically stable solid form of a fluoroquinolone
US5985893A · kind A · utility
12Cited by
2References
8Claims
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Key dates
| Filing date | May 1, 1996 |
| Grant date | Nov 16, 1999 |
| Priority date | — |
| Expiry date | May 1, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel crystal forms of the fluoroquinolone, [S-(R*,S*)]-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-[1-(methylam ino)ethyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid are disclosed. The forms are characterized by one methanol solvate form, and three anhydrous polymorphic forms, of which, Form III exhibits greatest stability and decreased hygroscopicity.
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