2-naphthamide derivatives and their therapeutic applications
US5985895A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jun 26, 1998 |
| Grant date | Nov 16, 1999 |
| Priority date | — |
| Expiry date | Jun 26, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/70
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to 2-naphthamide derivatives, in the form of bases or of salts, corresponding to the following general formula (I): ##STR1## in which: the Z-Y entity represents an N--CH.sub.2, C.dbd.CH or CH--CH.sub.2 group; PA1 R.sup.1 represents a hydrogen, fluorine, bromine or iodine atom or a hydroxyl, methoxy, nitrile or nitro group; PA1 R.sup.2 represents a hydrogen or bromine atom or a hydroxyl, methoxy, nitrile or nitro group; PA1 the R.sub.1 and R.sub.2 substituents both being situated on the same ring of the naphthamide unit or each being situated on one of the rings; PA1 R.sup.3 and R.sup.4 can be identical or different and each independently represent a hydrogen or chlorine atom or a methoxy or methyl group or an electron-withdrawing group. The invention also relates to their therapeutic applications as partial agonists of the dopamine D.sub.3 receptor. The invention applies more particularly to the treatment of neuropsychiatric conditions involving the dopamine D.sub.3 receptor, in particular psychotic and depressive states, to the treatment of drug-dependence states or to the treatment of disorders of a sexual nature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.