Method of making graft polymers
US5986015A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 16, 1997 |
| Grant date | Nov 16, 1999 |
| Priority date | — |
| Expiry date | May 16, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F2438/01
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is an improved method of making hydrophobic and hydrophilic graft polymers, which method comprises the steps of (a) reacting copolymerizable monomers to form an organic polymeric backbone having a weight average molecular weight of from about 15,000 grams/mole to about 200,000 grams/mole and a plurality of organic halide moieties covalently bonded to the polymeric backbone and pendant from the polymeric backbone and then, without a separate purification or isolation step; (b) reacting copolymerizable monomers with the organic halide moieties of the polymeric backbone by atom transfer free radical polymerization in the presence of a catalytic amount of a Cu(I) salt or other transition metal species complexed to a ligand suitable for solubilizing the salt in the reaction mixture to form a plurality of polymeric side chains covalently bonded to the polymeric backbone and pendant from the polymeric backbone and having a weight average molecular weight of from about 500 grams/mole to about 200,000 grams/mole, wherein the polymeric back bone and the plurality of polymeric side chains form hydrophilic and hydrophobic graft polymers having a weight average molecular weight of fro…
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