Genetic sequences and proteins related to alzheimer's disease
US5986054A · kind A · utility
21Cited by
2References
29Claims
0Family size
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Key dates
| Filing date | Jan 26, 1996 |
| Grant date | Nov 16, 1999 |
| Priority date | — |
| Expiry date | Jan 26, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/809
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention describes the identification, isolation and cloning of two human presenilin genes, PS-1 and PS-2, mutations in which lead to Familial Alzheimer's Disease. Also identified are presenilin homologue genes in mice, C. elegans and D. melanogaster. Transcripts and products of these genes are useful in detecting and diagnosing Alzheimer's disease, developing therapeutics for treatment of Alzheimer's disease, as well as the isolation and manufacture of the protein and the constructions of transgenic animals expressing the mutant genes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.