Process for the preparation of a 2-oxopyrrolidine compound
US5986107A · kind A · utility
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Key dates
| Filing date | Mar 2, 1999 |
| Grant date | Nov 16, 1999 |
| Priority date | — |
| Expiry date | Mar 2, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/273
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for producing a lactam of the formula ##STR1## wherein 2-bromo-4 chloro butyryl bromide or 2,4-dibromo butyryl bromide is coupled with 4-aminobenzonitrile to produce 4-(2,4-bromobutyrylamino)-benzonitrile, which is combined with sodium hydroxide, potassium hydroxide or potassium carbonate to produce 4-(3-bromo-2-oxopyrrolidin-1-yl)benzonitrile which is subjected to an excess of ammonium hydroxide to produce compounds of the formula (I).
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