Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability
US5989583A · kind A · utility
111Cited by
4References
20Claims
0Family size
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Key dates
| Filing date | Apr 2, 1997 |
| Grant date | Nov 23, 1999 |
| Priority date | — |
| Expiry date | Apr 2, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/352
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Lipophilic substances of poor oral bioavailability are mixed with at least one solid fat and phospholipid to obtain a dried solid composition suitable as an oral dosage form. The solid lipid compositions are exemplified for food additives or dietary supplements such as Coenzyme Q10 and for pharmaceuticals such as dexanabinol. The Coenzyme Q10-dry lipid mixtures shows improved drug release in vitro and enhanced oral bioavailability in vivo compared to a commercial CoQ10 formulation. The dexanabinol-dry lipid mixture similarly shows greatly enhanced oral bioavailability compared to known formulations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.