Method for screening for non-tetracycline efflux pump inhibitors
US5989832A · kind A · utility
42Cited by
0References
110Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 21, 1995 |
| Grant date | Nov 23, 1999 |
| Priority date | — |
| Expiry date | Apr 21, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are provided for screening for inhibitors of microbial efflux pumps including those which export antibiotics. The screening methods are based on the increase in the intracellular concentration of a compound, such as an antibiotic, when the bacterial cells are contacted with an efflux pump inhibitor. In addition, this invention provides pharmaceutical compositions containing such efflux pump inhibitors, and methods for treating microbial infections using those compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.