Ultrasonicated .alpha.-lipoic acid solutions for attenuating microvascular injury
US5990153A · kind A · utility
16Cited by
4References
16Claims
0Family size
Inventors
Key dates
| Filing date | May 5, 1998 |
| Grant date | Nov 23, 1999 |
| Priority date | — |
| Expiry date | May 5, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y115/01001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical composition comprising an ultrasonicated formulation of .alpha.-lipoic acid and an aqueous solution which may also contain other antioxidants and/or metal chelators is disclosed. Also disclosed is a method of ultrasonically preparing pure or mixed micelles of lipid-soluble antioxidants and .alpha.-lipoic acid in aqueous solutions for intravenous delivery to mitigate microvascular dysfunction in hemorrhagic shock and other conditions of acute microvascular injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.