Process for the preparation of 4-amino-.DELTA.4-3-ketosteroids via 4-nitro-.DELTA.4-3-ketosteroids
US5990328A · kind A · utility
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21Claims
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Key dates
| Filing date | Feb 24, 1999 |
| Grant date | Nov 23, 1999 |
| Priority date | — |
| Expiry date | Feb 24, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0066
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides 4-nitro-.DELTA..sup.4 -3-ketosteroids, their use as steroid C.sub.17-20 lyase and 5.alpha.-reductase inhibitors and to a novel process for preparing a compound of the formula: ##STR1## comprising sequentially: a) reacting a starting compound of the formula ##STR2## with an effective amount of a strong base at an elevated or suitable temperature for a time sufficient to create the corresponding thermodynamic dienolate, followed by addition of a neutral nitrating agent to produce the 4-nitrosteroid; and then; PA1 b) reacting the 4-nitrosteroid with a suitable reducing agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.