Capillary electrophoresis of transferrin glycoforms
US5993626A · kind A · utility
Inventors
Key dates
| Filing date | Jan 24, 1997 |
| Grant date | Nov 30, 1999 |
| Priority date | — |
| Expiry date | Jan 24, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/79
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A capillary electrophoresis method for resolving transferrin glycoforms in a sample is described. The capillary comprises a lumen, an inlet and an outlet. The lumenal surface of the capillary is charge-neutral and the capillary contains a buffer containing a polymeric matrix. The transferrin sample is contacted with the inlet of the capillary. A voltage is applied to the capillary such that the inlet is a cathode and the outlet is an anode and such that the voltage is effective for resolving transferrin glycoforms. A method for diagnosing chronic alcoholism or carbohydrate-deficient glycoprotein syndrome using CE to resolve abnormal populations of transferrin glycoforms is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.