Radiopharmaceutical compositions that include an inclusion complex of a cyclodextrin and a radio-halogenated fatty acid
US5993776A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 14, 1997 |
| Grant date | Nov 30, 1999 |
| Priority date | — |
| Expiry date | May 14, 2017 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to radio-pharmaceutical compositions that include an inclusion complex of a cyclodextrin and a radio-halogenated fatty acid. These complexes include a cyclodextrin such as .beta.-cyclodextrin, .gamma.-cyclodextrin and their derivatives, and a radio-halogenated fatty acid, in particular a fatty acid labelled with radioactive iodine such as 16-iodo 3-methyl hexadecanoic acid suitable for the examination of the myocardium by scintigraphy. The cyclodextrin allows the fatty acid to dissolve in aqueous solution without any addition of human blood albumin, while further improving the biodistribution of the fatty acid and its stability to heat.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.