Method for producing non-human animal having spinal cord injury
US5993779A · kind A · utility
Inventor
Key dates
| Filing date | Aug 28, 1997 |
| Grant date | Nov 30, 1999 |
| Priority date | — |
| Expiry date | Aug 28, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for producing a non-human animal suffering from a spinal cord injury, which comprises interrupting an aorta at least at two sites, thereby forming an isolated segment of the aorta including branched parts of radicular arteries feeding the spinal cord between the sites of interruption, bringing the spinal cord to ischemia, and regionally administering glutamic acid or aspartic acid to the segment and a method for evaluating a medicament for treating a spinal cord injury due to glutamic acid or aspartic acid, which comprises interrupting an aorta of a non-human animal at least at two sites, thereby forming an isolated segment of the aorta including branched parts of redicular arteries feeding the spinal cord between the sites of interruption, bringing the spinal cord to ischemia, and regionally administering glutamic acid or aspartic acid together with a medicament for treating a spinal cord injury to the segment or a method for evaluating a medicament for treating a spinal cord injury due to glutamic acid or aspartic acid, which comprises administering a medicament for treating a spinal cord injury to a non-human animal produced according to the above method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.