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US5993780A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Torsten Almen · Malmö, SE
• Sven Andersson · Malmö, SE
• Lars-Goran Wistrand · Oslo, NO
• Klaes Golman · Hørsholm, DK
• .O slashed.yvind Antonsen · Gjesåsen, NO
• Rune Fossheim · Oslo, NO
• Unni Nordby Wiggen · Rasta, NO
• Hakan Wikstrom · Groningen, NL
• Tomas Klingstedt · Lund, SE
• Ib Leunbach · Copenhagen, DK
• Arne Berg · Sandvika, NO
• Harald Dugstad · Oslo, NO

Key dates

• Filing date: Mar 24, 1997
• Grant date: Nov 30, 1999
• Expiry date: Mar 24, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/46
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C.sub.6 R.sub.5 moeity may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M.sub.1, two or three non-adjacent R groups in each C.sub.6 R.sub.5 moiety being iodine and at least one, and preferably two or three, R groups in each C.sub.6 R.sub.5 moiety being M or M.sub.1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C.sub.6 R.sub.5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M.sub.1 independently represents a C.sub.1-4 alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M.sub.1 moiety; with the proviso that where n is zero either at least one M.sub.1 group other than a hydroxymethyl or 1,2-dihydroxyethyl group is present or then if one hydroxymethyl or 1,2-dihydroxyethyl M.sub.1 group is present at least one nitrogen-attached or hydroxylated-C.sub.3-4 a…