Pharmaceutically acceptable fixed-dried human blood platelets
US5993804A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Dec 31, 1996 |
| Grant date | Nov 30, 1999 |
| Priority date | — |
| Expiry date | Dec 31, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2400/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.