Nitrosated and nitrosylated .alpha.-adrenergic receptor antagonist compounds, compositions and their uses
US5994294A · kind A · utility
27Cited by
11References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 18, 1996 |
| Grant date | Nov 30, 1999 |
| Priority date | — |
| Expiry date | Sep 18, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are nitrosated and nitrosylated .alpha.-adrenergic receptor antagonists, compositions of an .alpha.-adrenergic receptor antagonist (.alpha.-antagonist), which can optionally be substituted with at least one NO or NO.sub.2 moiety, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO.sup.+) or nitroxyl (NO.sup.-), or as the neutral species, nitric oxide (NO.cndot.); and uses for each of them in treating human impotence or erectile dysfunction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.