Pyridopyrimidones, quinolines and fused N-heterocycles as bradykinin antagonists
US5994368A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 25, 1997 |
| Grant date | Nov 30, 1999 |
| Priority date | — |
| Expiry date | Apr 25, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a compound of the formula: ##STR1## wherein Z is a group of the formula: ##STR2## in which X.sup.1 is N or C--R.sup.1, PA0 X.sup.2 is N or C--R.sup.9, PA0 X.sup.3 is N or C--R.sup.2, PA0 R.sup.1 is lower alkyl, PA0 R.sup.2 is hydrogen, lower alkyl, etc., PA0 R.sup.9 is hydrogen or lower alkyl, PA0 R.sup.3 is halogen, etc., PA0 R.sup.4 is halogen, etc., PA0 R.sup.5 is a group of the formula: ##STR3## A is lower alkylene, and Y is O, etc., and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods to using the same therapeutically in the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.