Di-and trisubstituted pyridines and their preparation
US5994540A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 30, 1998 |
| Grant date | Nov 30, 1999 |
| Priority date | — |
| Expiry date | Apr 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Substituted pyridines of the general formula: ##STR1## wherein R.sup.1 is hydroxyl or chlorine, and a) X is hydrogen or chlorine, R.sup.2 and R.sup.3 together are .dbd.O, R.sup.4 is a group of the formula --OR.sup.5 and R.sup.5 is hydrogen, C.sub.1 -C.sub.4 -alkyl or benzyl or PA1 b) X is hydrogen and R.sup.2, R.sup.3 and R.sup.4 together are .dbd.N--NH--, or PA1 c) X and R.sup.2 each is hydrogen and R.sup.3 and R.sup.4 together are --O--, or PA1 d) X and R.sup.2 each is hydrogen, R.sup.3 is hydroxyl and R.sup.4 is amino or hydroxy. The compounds are obtained by subjecting nicotine to microbiological oxidation to give 5-succinoyl-2-pyridone, followed by chemical reactions. The compounds are suitable as intermediates for the preparation of pharmaceutically active compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.