Targeted synthesis of protein in mammary gland of a non-human transgenic mammal
US5994616A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 25, 1994 |
| Grant date | Nov 30, 1999 |
| Priority date | — |
| Expiry date | Jan 25, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/85
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described are methods of targeting specific genes or DNA sequences encoding biologically active proteins to the mammary gland such that the DNA sequence is expressed in the mammary gland and the protein is secreted into the milk of the mammal. Also described is the production of transgenic nonhuman mammals whose germ line comprises a DNA gene complex containing a casein promoter, a casein enhancer, a DNA sequence which encodes a signal peptide and a DNA sequence encoding a biologically active protein. The milk containing the biologically active protein or the biologically active protein itself can be used in the making of diary products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.