Patent · US Expired

Acylated protein aggregates and their use as signal enhancers in an immunoassay for the detection of antibodies

US5998157A · kind A · utility

0Cited by

0References

9Claims

0Family size

Assignee

Roche Diagnostics GMBH · DE

Inventors

Urban Schmitt · Oberhausen, DE
Dittmar Schlieper · Weilheim, DE
Franz Schmid · Bayreuth, DE

Key dates

Filing date	Feb 29, 1996
Grant date	Dec 7, 1999
Priority date	—
Expiry date	Feb 29, 2016

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/54393
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention addresses protein aggregates that are acylated with --CO-- R groups, wherein R is a branched or non-branched C1-C4 alkyl residue which can be substituted with hydroxy, carboxy, SO.sub.3 H or PO.sub.3 H.sub.2 groups. These protein aggregates can be used to increase the intensity of signals and avoid false-positive results in immunoassays for the detection of antibodies. The inventions also adresses a reagent with a buffer and a binding reagent with an immunological binding partner containing said protein aggregate.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.