Salts of azelastine having improved solubility useful at providing a cytoprotective effect

US5998403A · kind A · utility

Assignee

• ASTA Pharma Aktiengesellschaft · DE

Inventors

• Helmut Hettche · Dietzenbach, DE
• Reinhard Muckenschnabel · Frankfurt, DE
• Gerhard Scheffler · Bielefeld, DE
• Ilona Fleischhauer · Offenbach, DE
• Wolfgang Morick · Frankfurt, DE

Key dates

• Filing date: Jul 28, 1998
• Grant date: Dec 7, 1999
• Expiry date: Jul 28, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to salts of azelastine having improved solubility in water. The salts of the present invention are prepared by reacting azelastine with acetic acid, gluconic acid, lactic acid, or malic acid. The azelastine salts are effective in providing a cytoprotective effect.