Heterocycles as inhibitors of leucocyte adhesion and as VLA-4 antagonists

US5998447A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hans Ulrich Stilz · Frankfurt am Main, DE
• Volkmar Wehner · Bischofsheim a.d.Rhön, DE
• Christoph Huels · Wackernheim, DE
• Dirk Seiffge · Hochheim, DE

Key dates

• Filing date: Nov 17, 1997
• Grant date: Dec 7, 1999
• Expiry date: Nov 17, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/0202
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I ##STR1## in which B, D, E, R, W, Y, Z, b, c, d, e, f, g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention relates to the use of compounds of the formula I, and of pharmaceutical preparations which contain such compounds, for the treatment and prophylaxis of diseases which are caused by an un desired extent of leucocyte adhesion and/or leucocyte migration or which are associated therewith or in which cell--cell or cell-matrix interactions play a part which are based on interactions of VLA-4 receptors with their ligands, for example of inflammatory processes, rheumatoid arthritis or allergic disorders, and it also relates to the use of compounds of the formula I for the production of pharmaceuticals for use in such diseases. It further relates to novel compounds of the formula I.