Biologically active fragments of IL-1.beta.
US5998578A · kind A · utility
3Cited by
5References
5Claims
0Family size
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Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Dec 7, 1999 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes stimulated with bacterial endotoxin. Human IL-1 is useful to induce the production of IL-2 by activated T-cells; it also acts on B-cells and NK-cells. The subject invention further concerns antibodies that are immunoreactive with human IL-1.beta. proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.