Preparation of asymmetric cyclic ureas using an alkali metal in liquid ammonia process
US5998614A · kind A · utility
1Cited by
6References
20Claims
0Family size
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Key dates
| Filing date | Jul 6, 1998 |
| Grant date | Dec 7, 1999 |
| Priority date | — |
| Expiry date | Jul 6, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D243/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention describes a method for the preparation of asymmetric N,N'-disubstituted cyclic ureas through the selective monodebenzylation of symmetric N,N'-disubstituted cyclic ureas using a dissolving metal reduction. The intermediates can be alkylated to give compounds which are useful as HIV protease inhibitors for the treatment of HIV infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.