Diagnostic and therapeutic alkylenediamine compounds and process

US6001330A · kind A · utility

Inventors

• David R. Elmaleh · Newton, US
• Robert N. Hanson · Newton, US
• Choi Sung-Woon · Norwood, US

Key dates

• Filing date: Sep 12, 1997
• Grant date: Dec 14, 1999
• Expiry date: Sep 12, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D241/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Diamine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The diamine compounds or serotonin are characterized by the formula: ##STR1## wherein: l, m and n can be the same or different and are an integer of 1 to 6; X, Y and Z can be the same or different and are hydrogen, halo, haloalkyl, (C.sub.1 -C.sub.6) alkyl, aryl, (C.sub.1 -C.sub.6) alkoxy, N-alkyl, (C.sub.2 -C.sub.6) acyloxy, N-alkylene, --SH, or --SR, wherein R is from the same group as R.sub.1 and R.sub.2 and can be the same or different than R.sub.1 and R.sub.2, amino, nitro, cyano, hydroxy, --C(.dbd.O) OR.sub.6, --C(.dbd.O) NR.sub.5 R.sub.4, NR.sub.3 R.sub.2, or S(.dbd.O).sub.k R.sub.1 wherein .sub.k is 1 or 2, and R.sub.4 to R.sub.6 are independently hydrogen or (C.sub.1 -C.sub.6) alkyl; PA1 R.sub.1, and R.sub.2 can be the same or different and are hydrogen, (C.sub.1 -C.sub.6) alkyl, hydroxyalkyl or mercaptoalkyl, --C(.dbd.O) OR.sub.1, cyano, (C.sub.1 -C.sub.6) alkenyl, (C.sub.2 -C.sub.6) alkynyl, or 1, 2, 4-oxadiazol-5-yl optionally substituted at he 3-position by W wherein any (C.sub.1 -C.sub.6) alky, (C.sub.…