Methods for disrupting GRB-7 complexes
US6001583A · kind A · utility
9Cited by
3References
5Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 6, 1995 |
| Grant date | Dec 14, 1999 |
| Priority date | — |
| Expiry date | Jun 6, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/20
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to compositions and methods for the prevention, prognostic evaluation, and treatment of oncogenic disorders, especially breast cancer, wherein a protein tyrosine kinase capable of complexing with a member of the SH2-and/or SH3-containing family of adaptor proteins is involved. In a preferred embodiment of the invention, the protein tyrosine kinase is the receptor protein tyrosine kinase HER2 or SHC polypeptide, and the adaptor protein is GRB-7, so that the protein tyrosine kinase/adaptor protein complex is a HER2/GRB-7 complex or a SHC/GRB-7 complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.