Methods for treating retroviral infection
US6001810A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 31, 1990 |
| Grant date | Dec 14, 1999 |
| Priority date | — |
| Expiry date | Aug 31, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides antiretroviral methods using the compounds of formula (I) EQU X-X1-P1-Val-Z-Leu-P2-Y wherein: PA1 Z is Statine or ACHPA; and when Z is Statine, PA1 X is H-Pro-paF, H-Pro-His, Ac-Tyr, Ac-NA, Ac-Trp, Ac-YOM, Ac-Phe, Ac-paF, H-His, Ac-His or Ac-Gly-Tyr-YOM, PA1 X1 is Pro Ser or Ac, PA1 P1 is Phe, paF or YOM, PA1 P2 is Phe or Leu, and PA1 Y is NH.sub.2, paF--NH.sub.2, His--NH.sub.2, Phe--NH.sub.2 or Tyr-Lue--NH.sub.2, provided that when X1 is Ac then there is no X residue; and when Z is ACHPA, PA1 X is H-Pro-His, H-Pro-paF, Ac-paF or Ac-His, PA1 P1 is Phe, PA1 P2 is Phe, and PA1 Y is paF--NH.sub.2 and His--NH.sub.2. The invention further provides methods for determining the retroviral protease inhibitory activity of compounds using viral polypeptides made using recombinant DNA techniques.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.