Bacterial inhibition with an oligosaccharide compound

US6001819A · kind A · utility

Assignee

• Neose Technologies, Inc. · US

Inventors

• Paul M. Simon · Wilmington, US
• David A. Zopf · Strafford, US
• Roger A. Barthelson · Kintnersville, US
• Karl F. Johnson · Willoughby Hills, US

Key dates

• Filing date: Apr 3, 1998
• Grant date: Dec 14, 1999
• Expiry date: Apr 3, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H3/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to compositions for the treatment of respiratory infections caused by a bacteria selected from the group consisting of S. pneumoniae, H. influenzae, H. parainfluenza, Burkholderia (Pseudomonas) cepacia, and a mixture thereof, comprising a binding inhibiting effective amount of the compound of Formula I, ##STR1## where R.sub.1 is H, (.beta.-1)GalNAc-, SO.sub.3 B (where B is H or a cation) or a sialic acid of Formula II; ##STR2## where R.sub.6, R.sub.7, R.sub.8, and R.sub.10 are each independently H, C.sub.1-6 acyl, lactyl, C.sub.1-6 alkyl, sulfate, phosphate, anhydro, a sialic acid of Formula II, (.alpha.-1)Fuc, (.beta.-1)Glc or (.beta.-1)Gal; PA2 R.sub.9 is NH--C.sub.1-6 acyl, glycolylamido, amino or hydroxyl; and PA2 A is H or a cation; PA1 R.sub.2 is H or (.alpha.-1)Fuc-; PA1 R.sub.3 and R.sub.4 are each independently OH or NHAc; PA1 R.sub.5 is H, SO.sub.3 B (where B is H or a cation), or a sialic acid of Formula II as defined above; ##STR3## Y is a chemical bond or a linking group; Z is H or a multivalent support; PA1 m is 0 or 1; and PA1 p is an integer of 1 to 1,000; with the proviso that the compound is not Gal.beta.1-4-GlcNAc.beta.1-3-Gal.be…