Process for producing quinazoline derivatives

US6001831A · kind A · utility

Assignee

• Clariant Corporation · DE

Inventors

• Theodor Papenfuhs · Frankfurt, DE
• Ralf Pfirmann · Griesheim, DE
• Stefan Krause · Munich, DE
• Doris Neumann-Grimm · Frankfurt, DE

Key dates

• Filing date: May 22, 1998
• Grant date: Dec 14, 1999
• Expiry date: May 22, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/96
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for producing 1,2,3,4-tetrahydro-2,4-dioxo-quinazoline-1-yl acetic acid derivatives of the formula (I) in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are mutually independently hydrogen, halogen, OH, NO.sub.2, (C.sub.1 -C.sub.6) alkoxy, (C.sub.1 -C.sub.6) alkyl, halogen-substituted (C.sub.1 -C.sub.6) alkyl, R.sup.5 is hydrogen, (C.sub.1 -C.sub.6) alkyl, phenyl where the alkyl or phenyl radical may also be substituted by halogen atoms; in which an anthranilic acid derivative of formula (II), in which R.sup.1 to R.sup.5 have the above meaning and R.sup.6 is hydrogen, (C.sub.1 -C.sub.6) alkyl or phenyl, where the alkyl or phenyl radical may also be substituted by halogen atoms, is reacted with a metal cyanate and hydrogen chloride in the presence of an inert solvent. ##STR1##