Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors

US6001839A · kind A · utility

Assignee

• BASF SE

Inventors

• David J. Calderwood · Nottingham, GB
• David Johnston · Nottingham, GB
• Paul Rafferty · Nottingham, GB
• Helen L. Twigger · Nottingham, GB
• Rainer Munschauer · Shrewsbury, US
• Lee D. Arnold · Rancho Santa Fe, US

Key dates

• Filing date: Mar 17, 1998
• Grant date: Dec 14, 1999
• Expiry date: Mar 17, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## including pharmaceutically acceptable salts thereof in which R.sub.1 represents hydrogen, 2-phenyl-1,3-dioxan-5-yl, a C.sub.1-6 alkyl group, a C.sub.3-8 cycloalkyl group, a C.sub.5-7 cycloalkenyl group or an (optionally substituted phenyl)C.sub.1-6 alkyl group wherein the alkyl, cycloalkyl and cycloalkenyl groups are optionally substituted by one or more groups of formula OR.sub.A in which R.sub.A represents H or a C.sub.1-6 alkyl group provided that a group of formula OR.sub.A is not located on the carbon attached to nitrogen; PA0 R.sub.2 represents hydrogen, a C.sub.1-6 alkyl group, a C.sub.3-8 cycloalkyl group, halo, hydroxy, an (optionally substituted phenyl)C.sub.1-6 alkyl group, optionally substituted phenyl or R.sub.4 ; and PA0 R.sub.3 represents a group of formula (a) ##STR2## in which the phenyl ring is additionally optionally substituted and A represents NH, O, NHSO.sub.2, SO.sub.2 NH, a C.sub.1-4 alkylene chain, NHCO, NHCO.sub.2, CONH, NHCONH, CO.sub.2 or S(O).sub.p in which p is 0, 1 or 2, or A is absent and R.sub.5 is attached directly to the phenyl ring; PA0 and R.sub.5 represents optionally substituted phenyl and, additionally, when A …