Heterocyclyl substituted dihydropyridines

US6001857A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Bodo Junge · Wuppertal, DE
• Wolfgang Hartwig · Wuppertal, DE
• Heinrich Meier · Wuppertal, DE
• Rudolf Schohe-Loop · Wuppertal, DE
• Zhan Gao · Beijing, CN
• Bernard Schmidt · Lindlar, DE
• Maarten Jonge · Overath, DE
• Teunis Schuurman · Overath, DE

Key dates

• Filing date: Jul 30, 1997
• Grant date: Dec 14, 1999
• Expiry date: Jul 30, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4-Heterocyclyl-substituted dihydropyridines are prepared by reacting appropriate aldehydes with .beta.-keto esters and aminocrotonic acid esters, or by esterifying 4-heterocyclyl-substituted dihydropyridinecarboxylic acids. The 4-heterocyclyl-substituted dihydropyridines can be employed in medicaments, in particular for the treatment of disorders of the central nervous system.