Patent · US Expired

Oligonucleotides with non-standard bases and methods for preparing same

US6001983A · kind A · utility

88Cited by
2References
6Claims
0Family size

Inventor

Key dates

Filing dateJan 17, 1995
Grant dateDec 14, 1999
Priority date—
Expiry dateJan 17, 2015

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12P19/34
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The disclosure describes new compositions of matter that are analogs of DNA and RNA containing heterocyclic bases that can form base pairs that fit the Watson-Crick geometry in that they involve a monocyclic six membered ring pairing with a fused bicyclic heterocyclic ring system composed of a five member ring fused with a six membered ring, with the orientation of the heterocycles with respect to each other and with respect to the backbone chain analogous to that found in DNA and RNA, but where these base pairs are joined by a pattern of hydrogen bonds different from that found in the AT and GC base pairs (a "non-standard base pair").

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.