Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions
US6002002A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 13, 1998 |
| Grant date | Dec 14, 1999 |
| Priority date | — |
| Expiry date | May 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/088
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel hydroxylamine derivatives represented by the general formula: wherein: PA1 X is O, --NH, or a group of formula NR', wherein R and R' are independently selected from alkyl, cycloalkyl, phenylalkyl, phenyl optionally substituted with halo, haloalkyl, PA1 alkyl, alkoxy or nitro; and a N-containing heterocyclic ring; PA1 R.sup.1 is H or alkanoyl, PA1 R.sup.2 is H or hydroxy optionally acylated with alkanoyl, and PA1 R.sup.3 is a group of the formula --NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently selected from PA1 H, alkyl, and a group of the formula --CO--NH--R wherein R is as defined above, or PA1 wherein R.sup.4 and R.sup.5 when taken together form a 5- to 7-membered heterocyclic ring which may optionally contain one additional hetero atom selected from nitrogen, oxygen and sulfur and which is optionally substituted with alkyl or phenylalkyl. Also provided are pharmaceutically acceptable acid addition salts of the compounds defined above, as well as pharmaceutical compositions containing the compounds or their acid addition salts as active ingredients. The compounds of the invention have been shown to have anti-ischemic effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.