Substituted 3-cyano quinolines

US6002008A · kind A · utility

Assignee

• American Cyanamid Company · US

Inventors

• Allan Wissner · Monsey, US
• Bernard D. Johnson · Stony Point, US
• Marvin Fred Reich · Suffern, US
• Middleton B. Floyd, Jr. · Suffern, US
• Douglas B. Kitchen · Schenectady, US
• Hwei-Ru Tsou · New City, US

Key dates

• Filing date: Mar 27, 1998
• Grant date: Dec 14, 1999
• Expiry date: Mar 27, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides compounds having the formula: ##STR1## wherein: X is cycloalkyl which may be optionally substituted; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally substituted; PA1 n is 0-1; PA1 Y is --NH--, --O--, --S--, or --NR--; PA1 R is alkyl of 1-6 carbon atoms; PA1 R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each, independently, hydrogen, halogen, alkyl, alkenyl, alkynyl, alkenyloxy, alkynyloxy, hydroxymethyl, halomethyl, alkanoyloxy, alkenoyloxy, alkynoyloxy, alkanoyloxymethyl, alkenoyloxymethyl, alkynoyloxymethyl, alkoxymethyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulfonamido, alkenylsulfonamido, alkynylsulfonamido, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy, carboalkyl, phenoxy, phenyl, thiophenoxy, benzyl, amino, hydroxyamino, alkoxyamino, alkylamino, dialkylamino, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, phenylamino, benzylamino, ##STR2## R.sub.5 is alkyl which may be optionally substituted, or phenyl which may be optionally substituted; PA1 R.sub.6 is hydrogen, alkyl, or alkenyl; PA1 R.sub.7 is chloro or bromo PA1 R.sub.8 is hydrogen, alkyl, am…