Transdermal protein delivery using low-frequency sonophoresis
US6002961A · kind A · utility
252Cited by
46References
6Claims
0Family size
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Key dates
| Filing date | Jul 25, 1995 |
| Grant date | Dec 14, 1999 |
| Priority date | — |
| Expiry date | Jul 25, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2037/0007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.