Lipophilic cyanine dyes with enchanced aqueous solubilty
US6004536A · kind A · utility
107Cited by
15References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 14, 1996 |
| Grant date | Dec 21, 1999 |
| Priority date | — |
| Expiry date | Aug 14, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/145555
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a family of cyanine dyes possessing lipophilic alkyl chains and either one or more reactive functional groups, bromo or chloro, or phenyl, sulfophenyl or polysulfophenyl substituents or combinations thereof. The dyes of the invention are useful for staining membranes in cells or isolated from cells, and are well-retained therein. Additionally, the reactive dyes of the invention are useful for preparing dye-conjugates, thereby conferring the membrane staining ability of the subject dye onto the resulting dye-conjugate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.