Adenovirus helper-free recombinant AAV Virion production
US6004797A · kind A · utility
23Cited by
1References
10Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 7, 1996 |
| Grant date | Dec 21, 1999 |
| Priority date | — |
| Expiry date | Nov 7, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producing rAAV virions are also provided. The methods can be practiced to produce commercially significant levels of rAAV particles without also generating significant levels of infectious helper virus or other contaminating by-products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.