In vitro generation of human dendritic cells
US6004807A · kind A · utility
23Cited by
3References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 25, 1996 |
| Grant date | Dec 21, 1999 |
| Priority date | — |
| Expiry date | Apr 25, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/11
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is provided for generating human dendritic cells in vitro by treating CD34.sup.+ cells with tumor necrosis factor-.alpha. and interleukin-3 or with GM-CSF. The invention also includes cellular compositions of dendritic cells produced by this method. Dendritic cells of the invention can be used widely as components in many diagnostic and therapeutic systems, including improved mixed lymphocyte reactions for assaying tissue rejection, adoptive immunotherapy of cancer, adoptive immunotherapy of HIV and other viral infections, and SCID-hu mice for human antibody production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.