Inositolglycans having insulin-like action

US6004938A · kind A · utility

Assignee

• Hoescht Aktiengesellschaft · DE

Inventors

• Wendelin Frick · Bad Camberg, DE
• Guenter Mueller · Pocking, DE

Key dates

• Filing date: Nov 26, 1997
• Grant date: Dec 21, 1999
• Expiry date: Nov 26, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H3/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to inositolglycans having insulin-like action. Specific compounds are provided having the formula I EQU A--Z--R (I) where A is the radical H--P(O)(OH)--, H--P(S)(OH)--, HO--P(S)(OH)--, HS--P(S)(OH)--, (C.sub.1 -C.sub.4)-alkyl-P(O)(OH)--, (C.sub.1 -C.sub.4)-alkyl-P(S)(OH)--, S(O).sub.2 (OR.sup.1)--, S(O)(OR.sup.1)--, NH.sub.2 --C(O)--, R.sup.1 R.sup.2 N--, R.sup.1 R.sup.2 N--C(O)--NH--, R.sup.1 O--SO.sub.2 --NH--, (C.sub.1 -C.sub.4)-alkyl-SO.sub.2 --, (C.sub.1 -C.sub.4)-alkyl-S(O)-- or R.sup.1 --S--, Z is 2 to 6 substituted or unsubstituted sugar radicals and R is substituted or unsubstituted inositol. The inventive compounds are suitable for the treatment of diabetes mellitus or noninsulin-dependent diabetes.