Protein-coated medical substrates for local delivery of genes and method of forming coatings on the substrates

US6004943A · kind A · utility

Assignees

• Inst. of Biomedical Engineering, Chinese Acdmy of Med. Science · CN
• Cardiovascular Inst. of Fu Wai Hospital, Chinese Acdmy of Med. Science · CN

Inventors

• Rui SHI · Kunming, CN
• Run-lin Gao · Beijing, CN

Key dates

• Filing date: Nov 26, 1996
• Grant date: Dec 21, 1999
• Expiry date: Nov 26, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K48/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is directed to an article, such as a medical device, for local delivery of genes. The article comprises a substrate coated with a cross-linked protein. The invention is also directed to a method for coating an article with cross-linked protein. An additive may be optionally incorporated into the coating. The crosslinked protein coating can strongly absorb genes. Thus, the coated article can be used to locally deliver genes to a target site. The coating of the invention exhibits excellent biocompatibility and biodegradability, and does not cause toxicity or side-effects.