Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors
US6004959A · kind A · utility
2Cited by
9References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 18, 1997 |
| Grant date | Dec 21, 1999 |
| Priority date | — |
| Expiry date | Apr 18, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.